free (w/ or w/o commercial version)… pyCNO 23 Oct 202523 Oct 2025 Python open-source package for Computational Nuclear Oncology PyCNO is an open-source Python package for computational nuclear oncology (CNO). It aims to provide advanced computational tools, including physiologically based pharmacokinetic (PBPK) and…
AI-Prostate Cancer… Automated mPCa lesion segmentation with self-configuring nnU-Net framework 26 Sep 202524 Oct 2025 An automated segmentation framework based on deep learning for metastatic prostate cancer (mPCa) lesions in whole-body [68Ga]Ga-PSMA-11 PET/CT images for the purpose of extracting patient-level prognostic biomarkers. AI-tool features Disease…
commercial-only… Voximetry Torch® 19 May 202519 May 2025 A commercial Dosimetry-Guided RadioPharmaceutical Therapy (RPT) Assessment Software by Voximetry offering GPU-Accelerated absorbed dose calculation and patient-drug interaction modeling individualized for the radionuclide, the drug, and the patient. Voximetry Torch® simplifies…
AI-NeuroImaging… ArcheD: residual neural network for prediction of cerebrospinal fluid amyloid-beta from amyloid PET 22 Feb 202524 Oct 2025 Task: A novel residual neural network ("ArcheD") to predict amyloid-beta cerebrospinal fluid (CSF) concentration directly from amyloid-beta (Αβ) PET scans, independent of the tracer, brain reference region or preselected regions…
AI-segmentation… TMTV-Net: Fully Automated Total Metabolic Tumor Volume Segmentation in Lymphoma PET/CT 16 Jan 202524 Oct 2025 Task: TMTV-Net, is specifically designed to automate TMTV segmentation from PET/CT scans. TMTV-Net demonstrates robust performance and adaptability in TMTV segmentation across diverse multi-site external datasets, encompassing various lymphoma subtypes.…
AI-segmentation… SEQUOIA 8 Dec 202424 Oct 2025 automated multiclass SEgmentation, QUantification, and visualizatiOn of the dIseased Aorta on hybrid PET/CT SEQUOIA is an automated pipeline for aortic PET/CT studies. First, it segments the ascending aorta, aortic arch,…
AI-segmentation… NanoMASK: Nanomedicine Multi-modal AI-based Segmentation for PharmacoKinetics 18 Sep 202424 Oct 2025 Task: Automatic organ and tumor segmentation for nanomedicine pharmacokinetic studies. Description: NanoMASK model is a 3D U-Net adapted deep learning tool capable of rapid, automatic organ segmentation of multimodal imaging…
AI-NeuroImaging… JuST_BrainPET: Juelich Segmentation Tool for Amino Acid PET Brain Tumor Segmentation 12 Aug 202424 Oct 2025 Task: Automated Brain Tumor Detection and Segmentation for Treatment Response Assessment Using Amino Acid PET Description: JuST_BrainPET: Juelich Segmentation Tool for Brain Tumor PET is a model trained for metabolic…
AI-NeuroImaging… brainPETNR: Brain PET Noise Reduction using a Frequency Attention Network 10 Apr 202424 Oct 2025 Task: Denoising of low-activity PET reconstruction of [11C]PiB and [18F]FE-PE2I images in neurodegenerative disorders Description: The brainPETNR framework utilizes a Frequency Attention Network (FAN) model for denoising of low-activity reconstructed brain…
AI-classification… Automated Detection of Focal Cortical Dysplasia With the FCDdetection Model Using Quantitative Multimodal Surface-Based Features 20 Mar 202424 Oct 2025 Task: Detection of Focal Cortical Dysplasia (FCD) lesions by combining quantitative multimodal surface-based features with machine learning and to assess its clinical value. Decription: The FCDdetection model is a neural…
AI-Large Language Models (LLMs)… Automatic Personalized Impression Generation for PET Reports Using Large Language Models(LLMs) 12 Feb 202424 Oct 2025 Task: Automatic Impression Generation for PET Reports Using Large Language Models (LLMs) Description: A collection of twelve open-source language models fine-tuned on a corpus of 37,370 retrospective PET reports were…
AI-NeuroImaging… DaT-SPECT-Segmentation: A tissue-fraction estimation-based segmentation framework for quantitative dopamine transporter SPECT 5 Feb 202424 Oct 2025 Task: Fully automated tissue-fraction estimation-based segmentation of the caudate, putamen, and Globus Pallidus (GP) from human brain DaT-SPECT images for quantitative assessments of Parkinson's Disease. Description: The DaT-SPECT-Segmentation model estimates the…
AI-PET denoising… FAN: Frequency Attention Network for Blind Noise Removal in Real Images 25 Jan 202424 Oct 2025 Task: Blind Noise Removal in Real Images Description: The FAN (Frequency Attention Network) model implements a method for blind image denoising that combines frequency domain analysis and attention mechanism, The…
AI-segmentation… MOOSE 27 Dec 202324 Oct 2025 Multi-organ objective segmentation MOOSE (Multi-organ objective segmentation) is a data-centric AI solution designed to streamline systemic Total-Body research by generating multilabel organ segmentations with high precision. Built on the robust…
free (w/ or w/o commercial version)… MAMBA 5 Nov 20235 Nov 2023 Multi-pAradigM voxel-Based Analysis: a computational cookbot The Matlab toolbox MAMBA is designed for the flexible application of statistical voxel-based (VB) analysis in different scenarios in medical imaging and radiation oncology. It provides…
free (w/ or w/o commercial version)… Dynamic PET 31 Oct 202331 Oct 2023 Dynamic positron emission tomography (PET) analysis Dynamic PET is designed for voxelwise analysis of reconstructed dynamic positron emission tomography (PET) scans, and also supports regional analysis. Dynamic PET provides a command line…
free (w/ or w/o commercial version)… Magia 30 Oct 202330 Oct 2023 Automated Brain PET Analysis Pipeline Magia is an automated processing pipeline for brain PET studies. Magia uses FreeSurfer to parcellate the brain into anatomical regions of interest, and performs kinetic…
free (w/ or w/o commercial version)… STARE 29 Oct 202331 Oct 2023 Source-to-Target Automatic Rotating Estimation STARE, Source-to-Target Automatic Rotating Estimation, is a MATLAB package for non-invasive estimation of the net influx rate (Ki) of irreversible Positron Emission Tomography (PET) radiotracers and…
free (w/ or w/o commercial version)… mfEVolve™ 28 Oct 202328 Oct 2023 Research Software for Multi-Tracer PET Imaging and Kinetic Analysis mfEVolve™ is a research-only software tool designed to facilitate multi-tracer and quantitative dynamic PET research studies by providing tools for processing,…
free (w/ or w/o commercial version)… NiftyPAD 26 Oct 202326 Oct 2023 Neuroimaging for the Prevention of Alzheimer's Disease NiftyPAD is a freely available, open source, Python-based software package for the versatile and quantitative analyses of static, full or dual-time window dynamic…
free (w/ or w/o commercial version)… FALCON 25 Oct 202325 Oct 2023 Fast Algorithms for Motion Correction FALCON is a Python-based advanced, fully-automatic PET image registration and motion correction tool designed to facilitate PET motion correction, both for head and total-body scans.…
free (w/ or w/o commercial version)… TriDFusion (3DF) image viewer 22 Mar 202327 Mar 2023 The TriDFusion (3DF) Image Viewer is a MATLABTM-based Multi-Fusion Imaging research software tool designed for physicians, physicist and academic researchers in medical imaging. It is a Multi-Modality & Multidimensional DICOM Image…
free (w/ or w/o commercial version)… RT-UTILS: A minimal Python library for RT Struct manipulation 22 Mar 202327 Mar 2023 RT-Utils has been developed to allow physicians and other users to view the results of segmentation performed on a series of DICOM images. It allows you to create or load…
free (w/ or w/o commercial version)… Open KM Initiative 7 Aug 202227 Mar 2023 The Open Kinetic Modeling (OpenKM) Initiative is aimed at opening up more educational opportunities and research resources on tracer kinetic modeling in the technical community of molecular imaging. The OpenKM…
free (w/ or w/o commercial version)… imlook4d 8 Mar 202227 Mar 2023 Imlook4d is a software tool for visualization of medical images (2D), volumes (3D) and time-dependent volumes (4D). Imlook4d is written in Matlab, which means that it has to be installed…
free (w/ or w/o commercial version)… APPIAN 4 Mar 20224 Mar 2022 APPIAN (Automated Pipeline for PET Image ANalysis) is an open-source automated software pipeline for analyzing PET images in conjunction with MRI. The goal of APPIAN is to make PET tracer…
free (w/ or w/o commercial version)… SAKE 3 Mar 20223 Mar 2022 Spectral Analysis Kinetic Estimation (SAKE): an integrated tool for quantification of PET data. SAKE is an open-source software designed for the easy application of spectral analysis in PET kinetic modeling…
free (w/ or w/o commercial version)… CILViewer 1 Mar 20221 Mar 2022 A simple Viewer for 3D data built with VTK and Python. The interactive viewer CILViewer2D provides: Orthoslicer (slice in x/y/z direction)keyboard interaction'x' slices on the YZ plane'y' slices on the…
free (w/ or w/o commercial version)… NAPARI 28 Feb 20221 Mar 2022 Multi-dimensional image viewer for python napari is a fast, interactive, multi-dimensional image viewer for Python. It’s designed for browsing, annotating, and analyzing large multi-dimensional images. It’s built on top of Qt (for the…
commercial-only… QUAD (Cedars Sinai Quantitative Diagnostic Software Group) 17 Feb 202217 Feb 2022 The Quantitative Diagnostic Software Group (QUAD) of the Department of Medicine at Cedars-Sinai, USA, seeks to develop software to allow computers to process and analyze three-dimensional images of the heart in…
free (w/ or w/o commercial version)… FIREVOXEL 1 Mar 20213 Jul 2023 FireVoxel is a medical imaging software for analysis and display of medical images. The emphasis is on fitting the kinetic models to the dynamic MRI, CT, PET, and SPECT acquisitions. Also…
free (w/ or w/o commercial version)… Phantom Analysis Toolkit (PAT) – Cloud-based service 24 Aug 202026 Feb 2022 SNMMI’s PET/CT Phantom Analysis Toolkit (PAT) Accreditation programs (e.g., Joint Commission, ACR) are increasingly requiring phantom-based PET/CT scanner measurements to provide evidence of quantitative accuracy and qualitative clinical image quality.…
free (w/ or w/o commercial version)… IAEA-NMQC 24 Aug 202024 Aug 2020 The IAEA Nuclear Medicine Quality Control (NMQC) Toolkit is a set of ImageJ (Fiji edition)-based codes developed in Java v.1.8 that allow the processing and analysis of nuclear medicine images…
free (w/ or w/o commercial version)… Mango: Multi-image Analysis GUI 15 Jun 202021 Aug 2020 Mango – short for Multi-image Analysis GUI – is a viewer for medical research images. It provides analysis tools and a user interface to navigate image volumes. Versions There are…
free (w/ or w/o commercial version)… QModeling: an Open-Source Toolbox for PET Kinetic Analysis 15 Jun 20206 Nov 2023 QModeling is a multi-platform toolbox for SPM to fit reference-region kinetic models (currently supporting SRTM, SRTM2, Patlak Reference and Logan Reference Plots) to dynamic PET imaging data. The toolbox was…
free (w/ or w/o commercial version)… SERA: Standardized Environment for Radiomics Analysis 15 Jun 202012 Aug 2020 The Standardized Environment for Radiomics Analysis (SERA) Package is a Matlab®-based framework developed at Johns Hopkins University that calculates radiomic features based on guidelines from the Image Biomarker Standardization Initiative…
free (w/ or w/o commercial version)… kinfitr: PET kinetic modeling using R 15 Jun 202012 Aug 2020 kinfitr is a package for PET Kinetic Modelling Using R. The main goal of this package is to equip PET modelers with great flexibility, while simultaneously making it easier to…
free (w/ or w/o commercial version)… itk-SNAP 15 Jun 202012 Aug 2020 ITK-SNAP is a software application used to segment structures in 3D medical images. It is an interactive software application that allows users to navigate three-dimensional medical images, manually delineate anatomical…
free (w/ or w/o commercial version)… ITK: The Insight Toolkit 15 Jun 202012 Aug 2020 Insight Toolkit (ITK), also known as Insight Segmentation and Registration Toolkit, is an open-source, cross-platform library that provides developers with an extensive suite of software tools for image analysis. Developed…
free (w/ or w/o commercial version)… CERR: Computational Environment for Radiological Research 21 Aug 201931 Mar 2021 CERR (pronounced 'sir'), stands for Computational Environment for Radiological Research. CERR is MATLAB based software platform for developing and sharing research results using radiation therapy treatment planning and imaging informatics.…
free (w/ or w/o commercial version)… Imager-4D: Viewer for dynamic PET studies with integrated Patlak and radiomics analysis 21 Aug 201912 Aug 2020 The Imager-4D is a novel PET viewer that allows the user to view dynamic PET data and to derive dynamic and radiomic parameters from that data. This includes the ability…
commercial-only… PMOD 1 Jan 201912 Aug 2020 Description: PMOD consists of a comprehensive set of user-friendly and powerful tools, each corresponding to a major task involved in image quantification. Due to their smooth interaction, the tools form…
free (w/ or w/o commercial version)… PyRadiomics (Radiomics Feature Extraction in Python) 1 Jan 201912 Aug 2020 PyRadiomics is an open-source python package for the extraction of Radiomics features from medical imaging. This package aims to establish a reference standard for Radiomics Analysis, and provide a tested…
free (w/ or w/o commercial version)… AMIDE 1 Jan 201912 Aug 2020 AMIDE stands for “Amide's a Medical Image Data Examiner”. The package is a completely free tool for viewing, analyzing, and registering volumetric medical imaging data sets. It has been written…
commercial-only… MIM Software 1 Jan 201912 Aug 2020 MIM Software Inc. provides practical imaging solutions in the fields of radiation oncology, radiology, nuclear medicine, neuroimaging, and cardiac imaging. MIM offers solutions for PC and Mac® workstations, as well…
commercial-only… Hermes Medical Solutions Software 1 Jan 201921 Mar 2023 Hermes Medical Solutions continuously innovates to enable faster and more personalized diagnosis and therapies in molecular imaging and nuclear medicine. For 47 years, we have empowered physicians and healthcare professionals…
commercial-only… MIRADA Medical Imaging Software Applications 1 Jan 201912 Aug 2020 Mirada Medical develops medical imaging software applications that provide simple and accessible solutions to complex image analysis problems in the diagnosis and treatment of cancer and other diseases. Through automation,…
commercial-only… CVIT (Cardiovascular Imaging Technologies) 1 Jan 201912 Aug 2020 Cardiovascular Imaging Technologies (CVIT) is a provider of cardiac specific research and technology solutions. CVIT offers a suite of software products for quantitative image reconstruction, review, analysis and kinetic modeling.…
commercial-only… OsiriX DICOM Viewer 1 Jan 201912 Aug 2020 With high performance and an intuitive interactive user interface, OsiriX is a widely used DICOM viewer across the globe. It is the result of more than 15 years of research…
free (w/ or w/o commercial version)… MIPAV (Medical Image Processing, Analysis and Visualization) 1 Jan 201912 Aug 2020 The MIPAV (Medical Image Processing, Analysis, and Visualization) application enables quantitative analysis and visualization of medical images of numerous modalities such as PET, MRI, CT, or microscopy. Using MIPAV's standard…
free (w/ or w/o commercial version)… IBEX (Imaging Biomarker Explorer) 1 Jan 201912 Aug 2020 IBEX (imaging biomarker explorer) is an open infrastructure software platform that flexibly supports common radiomics workflow tasks such as multimodality image data import and review, development of feature extraction algorithms,…
free (w/ or w/o commercial version)… 3DSlicer 1 Jan 201912 Aug 2020 3DSlicer is an open source software platform for medical image informatics, image processing, and three-dimensional visualization. Built over two decades through support from the National Institutes of Health and a…
free (w/ or w/o commercial version)… FreeSurfer 1 Jan 201918 Oct 2023 FreeSurfer is an open-source software suite for processing and analyzing (human) brain MRI images. It can support Skullstripping, Image Registration, Subcortical Segmentation, Cortical Surface Reconstruction, Cortical Segmentation, Cortical Thickness Estimation,…
commercial-only… SAAM II (Simulation Analysis and Modeling) 1 Jan 201929 Jul 2024 SAAM II is a modeling, simulation, and analysis software package, which supports the development and statistical calibration of compartmental models in biological, metabolic, and pharmaceutical systems. Used worldwide by more…
commercial-only… MedView 1 Jan 201912 Aug 2020 MedView from MedImage is an imaging exam reading software for nuclear medicine, nuclear cardiology and PET/CT. MedView can be used as a stand-alone solution or integrated with PACS. Single station or…
free (w/ or w/o commercial version)… VSPLINE (Vector spline smoothing package) 1 Jan 201912 Aug 2020 VSPLINE package implements previously published smoothing spline algorithms. Official Website Source Code Tutorials Reference Paper
free (w/ or w/o commercial version)… LIFEx 1 Jan 201912 Aug 2020 LIFEx is a freeware enabling the calculation of a broad range of conventional, textural and shape indices from PET, MR, US and CT images. The software is written in Java…
free (w/ or w/o commercial version)… UCLA Tracer Kinetic Model Fitting (TKMF) Program 1 Jan 201912 Aug 2020 The Tracer Kinetic Model Fitting (TKMF) Program is a server-based tracer kinetic analysis software program that is accessible through the Internet. It provides the general capability of tracer kinetic model…
free (w/ or w/o commercial version)… Carimas 1 Jan 201912 Aug 2020 Carimas is a general medical imaging processing platform developed in Turku PET Centre in Finland. Carimas is for research use only – not for use in diagnostic procedure. Originally, Carimas…
free (w/ or w/o commercial version)… Fiji (just as ImageJ) 1 Jan 201912 Aug 2020 Fiji is an image processing package—a "batteries-included" distribution of ImageJ, bundling a lot of plugins which facilitate scientific image analysis. Fiji is easy to install and has an automatic update function, bundles a lot of…
free (w/ or w/o commercial version)… MIAKAT 1 Jan 201912 Aug 2020 MIAKAT™ is a fully quantitative suite of analysis tools for PET neuroimaging data. The software includes functionality for motion correction of dynamic image sequences, neuoranatomical parcellation of regions of interest…
free (w/ or w/o commercial version)… XNAT (the Extensible Neuroimaging Archive Toolkit) 1 Jan 201912 Aug 2020 XNAT is an open source imaging informatics platform developed by the Neuroinformatics Research Group at Washington University. XNAT was originally developed at Washington University in the Buckner Lab, which is now…
free (w/ or w/o commercial version)… SPM – Statistical Parametric mapping 1 Jan 201912 Aug 2020 Statistical Parametric Mapping (SPM) refers to the construction and assessment of spatially extended statistical processes used to test hypotheses about functional imaging data. These ideas have been instantiated in software…
commercial-only… VivoQuant 1 Jan 201912 Aug 2020 VivoQuant® from Invicro is a DICOM compliant post-processing suite for image data combining fundamental viewing functionality with advanced analysis capabilities. VivoQuant® supports data from most imaging modalities including MR, PET, SPECT, CT,…
free (w/ or w/o commercial version)… Vinci (Volume Imaging in Neurological Research) 1 Jan 201912 Aug 2020 VINCI (“Volume Imaging in Neurological Research”) was designed for the visualization and analysis of volume data generated by medical tomography systems with special emphasis on the needs for brain imaging…
free (w/ or w/o commercial version)… PETPVC: toolbox for partial volume correction in PET 1 Jan 201912 Aug 2020 PETPVC is a toolbox for partial volume correction (PVC) in positron emission tomography (PET). The package offers a method for applying partial volume correction (PVC) to positron emission tomography (PET)…
free (w/ or w/o commercial version)… QIICR (Quantitative Image Informatics for Cancer Research) 1 Jan 201912 Aug 2020 QIICR: open source imaging informatics tools based on 3D Slicer to support research workflows of the NCI Quantitative Imaging Network.QIICR is supported by the NIH National Cancer Institute ITCR program,…
free (w/ or w/o commercial version)… NiftyPET 1 Jan 201912 Aug 2020 NiftyPET is an open source Python package for image reconstruction and analysis with uncertainty estimation as well as support for high-throughput parallel processing using GPU computing. The pipeline of the…
free (w/ or w/o commercial version)… ImageJ (Image Processing and Analysis in Java) 1 Jan 201912 Aug 2020 ImageJ is a public domain Java image processing program inspired by NIH Image for the Macintosh. It runs, either as an online applet or as a downloadable application, on any…
free (w/ or w/o commercial version)… SIRF (Synergistic Image Reconstruction Framework) for Biomedical Imaging 1 Jan 201912 Aug 2020 The CCP (Collaborative Computational Project) in synergistic image reconstruction for biomedical imaging (SyneRBI), formerly known as CCP PET-MR (Collaborative Computational Project in synergistic PET-MR image reconstruction), project has led to…
NMMItools 